ODONTOIATRA > SUPERFICIE ZIRTI

La superficie implantare ideale dovrebbe avere le caratteristiche per diventare la nuova nicchia per i precursori mesenchimali, sostituendo quella midollare. La comprensione dei fattori che compongono questa nicchia, la conoscenza degli stimoli che questa riesce a conferire alle cellule, in particolare ai precursori cellulari in grado di differenziarsi in cellule ossee mature è alla base del contemporaneo approccio alle superfici e ai materiali implantari: una vera e propria ingegneria tissutale in grado di ottimizzare le risposte ossee e massimizzare l’integrazione dell’impianto nel suo contesto.

Prof. Guido Maria Macaluso – Università di Parma

LA SUPERFICIE IMPLANTARE: UNA NICCHIA SOSTITUTIVA

Introduzione a Scientifica vol.I – gennaio 2011

La sicurezza della superficie ZirTi

Dalla consapevolezza dell’importanza delle caratteristiche fisico-chimiche della superficie a contatto con l’osso nasce la ZirTi, ottenuta attraverso un processo di sabbiatura con ossido di zirconio, seguito da mordenzatura.

 

Questi passaggi conferiscono alla superficie una topografia a cui gli osteoblasti hanno dimostrato di adattarsi intimamente e sulla quale proliferare rapidamente. La ZirTi, con la sua rugosità di 1.3-1.7 μm, rientra perfettamente nei parametri definiti dalla 2° Consensus Conference dell’EAO (COIR, Vol. 20, Supp 4, September 2009) per ottenere un ottimo BIC.

Ingrandimenti di osteoblasti primari sulla superficie ZirTi: nelle immagini è visibile l’intimo adattamento di una cellula sui picchi che caratterizzano la ZirTi, grazie ad una sezione ottenuta con FIB (Focused Ion Beam).

 

Immagine per gentile concessione Prof. Macaluso, Università di Parma, Dipartimento di Medicina e Chirurgia - Centro di Odontoiatria.

Negli anni una serie di lavori scientifici sulla ZirTi ha dimostrato che la superficie, grazie alle sue peculiari caratteristiche chimiche e morfologiche, riesce a condizionare e modulare positivamente la risposta cellulare, influenzando la capacità replicativa e il potenziale differenziativo. In ultima analisi, la ZirTi favorisce formazione di tessuto osseo, una condizione irrinunciabile per ottenere l’integrazione e, quindi, il successo implantare.

BIBLIOGRAFIA:

Caneva M., Salata L., Scombatti de Souza S., Baffone G., Lang N.P., Botticelli D.
Influence of implant positioning in extraction sockets on osseointegration: hystomorphometrical analyses in dogs
Clinical Oral Implant Research 21, 2010, 43-49

 

Caneva M., Salata L., Scombatti de Souza S., Bressan E., Botticelli D. Lang N.P.
Hard tissue formation adjacent to implants of various size and configuration immediately placed into extraction sockets. An experimental study in dogs
Clinical Oral Implant Research, 21 (9), 2010: 885-890, DOI 10,1111/J.1600-0501,2010,01931,X

 

Caneva M., Botticelli D., Salata L., Scombatti de Souza S., de Cervalho Cardoso L., Lang N.P.
Collagen membranes at immediate implants. A hystomorphometric study in dogs
Clinical Oral Implant Research, 21 (9), 891-897, DOI: 10.1111/j.1600-0501.2010.01946.x

 

Caneva M., Botticelli D., Salata L., Scombatti de Souza, S., Bressan E.
Flap versus flapless surgical approach at immediate implants. A hystomorphometric study in dogs
Clinical Oral Implant Research, 2010, 21 (12): 1314-1319, DOI: 10.1111/j.1600-0501.2010.01959.x

 

Caneva M., Botticelli D., Stellin, E., Salata L.A., Souza S.L.S., Lang N.P.
Magnesium-enriched hydroxyapatite at immediate implants. A histomorphometric study in dogs.
Clinical Oral Implants Research, 2011 22(5): 512-517, DOI 10,1111/j.1600-0501,2010,02040,x

 

Scala A., Botticelli D., Silveira Faeda R., Garcia Rangel I. Jr., Oliveira J.A. & Lang N.P.
Lack of influence of the Schneiderian membrane in forming new bone apical to implants simultaneously installed with sinus floor augmentation. An experimental study in monkeys.
Clinical Oral Implant Research,  23, 2012 175–181

 

Baffone G. M., Botticelli D., Pantani F., Carvalho Cardoso L., Schweikert M.T., Lang N.P.
Influence of various implant platform configurations on peri-implant tissue dimensions.  An experimental study in the dog.
Clinical Oral Implant Research, 22, 2011; 438-444, doi: 10.1111/j.1600-0501.2010.02146.x

 

Rossi F, Botticelli D, Pantani F, Pereira FP, Salata LA, Lang NP
Bone healing pattern in surgically created circumferential defects around submerged implants: an experimental study in dog
Clin. Oral Impl. Res 23, 2012; 41–48.

 

Caneva M, Botticelli D, Pantani F, Baffone GM, Rangel jr IG, Lang NP
Deprotenized bovine bone mineral in marginal defects at implants istalled immediately into extraction sockets: an experimental study in dogs
Clinical Oral Implant Research,  23, 2012; 106–112.

 

Caneva, M., Botticelli, D., Rossi, F., Carvalho Cardoso, L., Pantani, F. & Niklaus P. Lang.
Influence of implants with different sizes and configurations installed immediately into extraction sockets on peri-implant hard and soft tissues. An experimental study in dogs.
Clinical Oral Implant Research,  23, 2012, 396–401

 

De Santis E, Lang NP, Scala A, Vigano` P, Salata LA, Botticelli D.
Healing outcomes at implants installed in grafted sites: an experimental study in dogs.
Clinical Oral Implant Research,  23, 2012, 340–350

 

Caneva M, Botticelli D, Morelli F, Cesaretti G, Beolchini M, Lang NP
Alveolar process preservation at implants installed immediately into extraction sockets using deproteinized bovine bone mineral – an experimental study in dogs.
Clinical Oral Implant Research,  00, 2011, 1–8

 

Caneva M, Botticelli D, Vigano` P, Morelli F, Rea M, Lang NP.
Connective tissue grafts in conjunction with implants installed immediately into extraction sockets. An experimental study in dogs Connective tissue grafts in conjunction with implants installed immediately into extraction sockets. An experimental study in dogs
Clinical Oral Implant Research, 2013; 24: 50-56, DOI: 10.1111/j.1600-0501.2012.02450.x, 

 

Sivolella S, Bressan E, Salata LA, Urrutia ZA, Lang NP, Botticelli D.
Osteogenesis at implants without primary bone contact - An experimental study in dogs
Clinical Oral Implant Research,  2012; 23: 542–549, DOI: 10.1111/j.1600-0501.2012.02423.x,

 

De Santis E, Lang NP, Cesaretti G, Mainetti T, Beolchini M,
Healing outcomes at implants installed in sites augmented with particulate autologous bone and xenografts. An experimental study in dogs.
Clinical Oral Implants Research, 2013; 24: 77-86, DOI: 10.1111/j.1600-0501.2012.02456.x

 

Baffone G, Botticelli D, Pereira FP, Favero G, Schweikert M, Lang NP.
Influence of buccal bony crest width on marginal dimensions of peri-implant hard and soft tissues after implant installation. An experimental study in dogs
Clinical Oral Implants Research, 2013; 24: 250-254, DOI: 10.1111/j.1600-0501.2012.02512.x

 

Calvo-Guirado JL, Boquete-Castro A, Negri B,  Delgado Ruiz R, Gomez-Moreno G, Iezzi G.
Crestal bone reactions to immediate implants placed at different levels in relation to crestal bone. A pilot study in Foxhound dogs.
Clinical Oral Implant Research, Early View, First Published online on 2013, January 25th, DOI: 10,1111/clr.12110

 

Rossi F, Lang NP, De Santis E, Morelli F, Favero G, Botticelli D.
Bone-healing pattern at the uyrface of titanium implants: an experimental study in the dog
Clinical Oral Implant Research, Early View, First Published online on 2013, January 4th, DOI: 10,1111/clr.12097

 

Sivolella S, Bressan E, Salata LA, Quinones ME, Urrutia ZA, Lang NP, Botticelli D. 
Deproteinized bovine bone mineral particles and osseointegration of implants without primary bone contact: an experimental study in dogs.
Clinical Oral Implant Research, Early View, First Published online April 8th 2013 doi: 10.1111/clr.12154

 

Bengazi F, Botticelli D, Favero V, Perini A, Urbizo velez J, Lang NP
Influence of presence or absence ok keratinized mucosa on the alveolar bony crest level as it relates to different buccal margin bone thicknesses. An experimental study in dogs
Clinical Oral Implant Research, 00, 2013, 1-7, Accepted 26 June 2013, first published on line on 29/07/2013, DOI 10,1111/clr.12233

 

Bressan E., Lang NP, Corazza B, Rizzi S, Almagro Urrutia Z, Botticelli D
The Platform Switching concept revisited. An experimental study in dogs
Clinical Oral Implant research, 2013:1-5, doi: 10.1111/clr.12263, published on line early view in ahead of print in September 2012

 

Bengazi F, Lang NP, Caroprese M, Velez JU, Favero V, Botticelli D
Dimensional changes in soft tissues around dental implants following free gingival grafting: an experimental study in dogs
Clinical Oral Implant Research, 00, 2013: 000-000, doi 10.1111/CLR.12280, Early view in ahead of print, accepted  9th September 2013

 

Baffone G, Lang NP, Pantani F, Favero G, Ferri M, Botticelli D
Hard and soft tissue changes around implants installed in regular-sized  and reduced alveolar bony ridges. An epxerimental study in dogs
Clinical Oral Implant Research, 00, 2013: 1-6, doi 10.1111/clr.12306, Early view in ahead of print, accepted 28 October 2012

 

Negri B, López Marí M, Maté Sánchez de Val JE, Iezzi G, Bravo González LA, Calvo Guirado JL
Biological width formation to immediate implants placed at different levels in relation to the crestal bone -  an experimental study in dogs
Clinical Oral Implant Research, 00, 2014: 1-11, doi 10.1111/clr.12345, Early view in ahead of print, accepted 06 January 2013

 

Mainetti T, Lang N, Bengazi F, Sbricoli L, Soto Cantero L, Botticelli D.
Immediate loading of implants installed in a healed alveolar bony ridge or immediately after tooth extraction: an experimental study in dogs
Clinical Oral Implant Research, 00, 2014: 1-8, doi 10.1111/clr.12389, Early view in ahead of print, accepted 5 March 2014

 

Caneva M, Lang NP, Calvo Guirado JL,  Spriano AM, Iezzi G, Botticelli D.
Bone healing at bicortically istalled implants with different surface configurations. An experimental study in rabbits
Clinical Oral Implant Research, 00, 2014: 1-7, Early view in ahead of printing, accepted 29 July 2014, doi:10.1111/clr.12475

 

Morelli F,Lang NP, Bengazi F, Baffone D, Vila Morales CD, Botticelli D.
Influence of bone marrow on osseointegration in long bones: an experimental study in sheep
Clinical Oral Implant Research, 00, 2014: 1-7, Early view in ahead of printing, accepted 29 August 2014, doi:10.1111/clr.12487

 

F. Carinci,  F. Pezzetti , S. Violina, F. Francioso, D. Arcelli , J. Marchesini, A. Piattelli
Analysis of MG63 Osteoblastic-cell response to a new nanoporous implant surface by means of a microarray technology
Clinical Oral Implant Research, 15: 180-186, 2004

 

Postiglione L., Di Domenico G., Ramaglia L., Di Lauro A.E., Di Meglio F., Montagnani S.
Different titanium surfaces modulate the bone phenotype of SaOS-2 osteoblast-like cells.
European journal of histochemistry; EJH, 48 (3): 213-22, 2004

 

Conserva E. , Tealdo T., Acquaviva A., Bevilaqua M., Volpara G. - Pera G.
Analisi morfologica e valutazione della proliferazione cellulare in relazione a differenti trattamenti di superficie implantare: studio in vitro
 Implantologia 2005, 4: 303-317 2005

 

Passeri G., Cacchioli A., Ravanetti F., Galli C., Elezi E., Macaluso G.M.
Adhesion pattern and growth of primary human osteoblastic cells on five commercially available titanium surfaces
Clinical Oral Implant Research,  21(11), 2010; 756–765, DOI: 10,111/j,1600-0501.2009.01906.x

 

Ramaglia L, Postiglione L, Di Spigna G., Capece G., Salzano S, Rossi G
Sandblasted-acid-etched titanium surface influences in vitro. The biological behaviour of SaOS2 human osteoblast-like cells
Dental Material Journal, 30(2) 2011, 183-192

 

Galli C, Piemontese M, Meikle ST, Santin M, Macaluso GM, Passeri G.
Biomimetic coating with phosphoserine-tethered poly(epsilon-lysine) dendrons on titanium surfaces enhances Wnt and osteoblastic differentiation
Clinical Oral Implant Research, Early View, First Published online on 2012, December 5th, DOI: 10,1111/clr.12075

 

L.Postiglione, G.Di Domenico, L.Ramaglia, S.Montagnani, S.Salzano,  F.Di Meglio,  L. Sbordone,  M. Vitale,  G. Rossi
Behavior of SaOS-2 cells cultured on different titanium surfaces
Journal of Dental Research, 82 (9): 692-696, 2003

 

Pappalardo S., Baglio O.A., Carlino P., Grassi F.R.
Scanning Electron Microscope Analysis of Different Implant Surfaces: a Comparative Study
European Journal of Implant Prosthodontics, 1 (1): 25-34; 2005

 

Micarelli C, Canullo L, Grusivin MG, Penarrocha Oltra D
Cell adhesion to titanium abutments after different cleaning procedures
Clinical Oral Implant Research, 24(Suppl.9), 2013: 79-101